One of the preeminent medical schools in the nation today, Johns Hopkins University has played a unique role in the history of medicine. When it first opened its doors in 1893, medicine was a rough-and-ready trade, but it soon evolved into a rigorous science. Underscoring that the school became a nexus of talented, devoted, and influential individuals, this inspiring overview recounts the stories of John Shaw Billings, Max Brödel, Mary Elizabeth Garrett, William Halsted, Jesse Lazear, Dorothy Reed Mendenhall, William Osler, Helen Taussig, Vivien Thomas, and William Welch.